Development and manufacturing of sprays

Sprays are a widely used treatment option for ENT (ear, nose, and throat) ailments, combining precise dosage, ease of use, and targeted efficacy close to the mucous membranes.

Volume_Filling (2)
Material: PET, PE, HDPE or glass vials coated with a PE film, oval or round
Volume_Filling (1)
Filling volume: 5 to 30 ml
solutions supensions
Formulations: liquid solutions, slightly viscous liquids, and suspensions.
Sprays
Stérile
Clip-on dosing pump or nebulizer cannula, screw cap
personnalisation
Inkjet printing, single and double labeling
statut
Statuses: Medical device, medication, homeopathy, veterinary

Advantages of the technology

Choosing a spray means choosing precision, simplicity, and targeted efficacy.

  • In-line sterilization of the solution by 0.2µm sterilizing filtration
  • Turnkey products, from concept to finished product
  • A multidisciplinary and international team to meet all your regulatory, development, or manufacturing needs
  • Various packaging options: size, format, and material

The list of molecules compatible with our ENT solutions continues to expand, including: xylometazoline, seawater, isotonic saline solutions, beclomethasone, mometasone, melatonin, naphazoline, dexamethasone, oxymetazoline, and carragelose.

Manufacturing sites and capacity

Out-licensing - our turnkey documentation and products in Spray packaging

 Table: Out-licensing - our turnkey documentation and products in Spray packaging
Spray Volume Category Status Dossier Country
COP - Nasal spray for adults and children 2y+ (sterile without preservative) 20 mL Cough & cold MD (IIa) CE mark Contact us
COPK - Nasal spray for children 1y+ (sterile without preservative) 20 mL Cough & cold MD (IIa) CE mark Contact us
COF - Nasal spray for adults and children 1y+ (sterile without preservative) 20 mL Flu-like illness MD (IIa) CE mark Contact us
COFS/AKUT - Nasal spray for adults and children 1y+ (sterile without preservative) 20 mL Decongestant MD (IIa) CE mark Contact us
CALLERGIN - Nasal spray for adults and children 1y+ (sterile without preservative) 20 mL Allergic rhinitis MD (IIa) CE mark Contact us
RAC - Throat spray for adults and children 1y+ (sterile without preservative) 20 mL Cough & Cold MD (IIa) CE mark Contact us

End-to-end support from the initial phases: from concept to product

Manufacturing

From technology transfer to industrial manufacturing, from small clinical batches to commercial volumes.

Development

Formulation and analytical development, manufacture of clinical batches, stability studies, and expertise in ophthalmic development.

Out-licensing

Access medicines and medical devices that are ready to be registered and marketed.
 Content type:  Resource  Resource

Carragelose Mode of Action

The Science Behind Carragelose’s Protective Action ⚪ Virus-blocking Unspecifically blocks respiratory viruses causing the common cold ⚪ Allergen-blocking Blocks allergens…

Got questions? - Consult our FAQ

Unither provides a fully integrated CDMO approach, covering:

  • formulation and analytical development
  • clinical batch manufacturing and stability studies
  • industrial scale-up and commercial production

With dedicated expertise in ENT applications, Unither enables the development of ready-to-market spray solutions, from concept to finished product.

Spray performance relies on the precise interaction between formulation, pump system and container.
Unither ensures:

  • controlled dose delivery and reproducibility
  • compatibility between formulation and device

This results in efficient, localized treatment with improved patient adherence.

Selecting the right spray format depends on target indication, viscosity of the formulation, and patient use conditions.
Unither supports this decision by defining the optimal combination of:

  • formulation type (solution, slightly viscous liquid, suspension)
  • delivery system (dosing pump or nebulizer cannula)
  • container material (PET, PE, HDPE, glass)

This ensures accurate delivery, patient comfort and regulatory alignment from the early stages of development.